Anti-Inflammatory and Anti-nociceptive Effects of Ethanolic Extract of Setaria megaphylla Leaves in Rodents

ed by: African Index Medicus (WHO), CAB Abstracts, Index Copernicus, Global Health Abstracts, Asian Science Index, Index Veterinarius, Bioline International , African Journals online Full-text available at http://www.ajbrui.com http://www.bioline.br/md http://www.ajol.com Received: April 2006 Accepted (Revised): July 2006 Published September 2006 Full Length Research Article Anti-Inflammatory and Anti-nociceptive Effects of Ethanolic Extract of Setaria megaphylla Leaves in Rodents Okokon, Jude E. Antia, Bassey S. Ita, Basil N 1 Dept. of Pharmacology & Toxicology, Faculty of Pharmacy University of Uyo, Uyo – Nigeria 2 Dept of Chemistry, University of Uyo, Uyo – Nigeria ABSTRACT The ethanolic leaf extract of Setaria megaphylla (100-300 mg/kg) was investigated for pharmacological properties against egg white albumin induced inflammation, Chemical as well as thermalinduced pain. The extract demonstrated a dose – dependent antiinflammatory and antinociceptive activities. These activities were comparable to that of ASA (100mg/kg). The leaf extract possess anti inflammatory and analgesic properties, which can be exploited in health care (Afr. J. Biomed. Res. 9: 229 – 233)The ethanolic leaf extract of Setaria megaphylla (100-300 mg/kg) was investigated for pharmacological properties against egg white albumin induced inflammation, Chemical as well as thermalinduced pain. The extract demonstrated a dose – dependent antiinflammatory and antinociceptive activities. These activities were comparable to that of ASA (100mg/kg). The leaf extract possess anti inflammatory and analgesic properties, which can be exploited in health care (Afr. J. Biomed. Res. 9: 229 – 233)